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Investors KidneyIntelX

Goodbye, Kidney Disease.
Hello, Kidney Health.

Traditional clinical kidney measurements are flawed.

Physicians typically look at estimated GFR and urinary albumin creatinine ratio levels, but they are inadequate in identifying those select patients who are more likely to experience progressive decline in kidney function.

That changes now… with kidney bioprognosis™.

Renalytix is the global founder and leader in the new field of bioprognosis for kidney health. We’ve engineered a new solution that successfully enables early-stage, progression risk assessment, when it counts the most.

BioprognosisTM definition: the use of proven, highly prognostic biomarkers, select clinical features, and machine learning to best predict outcomes and to promote and preserve patient health.

Our proprietary platform, KidneyIntelXTM, is at the core of our solution offering.

With KidneyIntelX, we take diverse and proprietary data inputs and maximize their value through our AI-enabled algorithm. This allows us to generate an accurate kidney disease risk score – identifying those patients with kidneys at the most risk – to guide ongoing, clinical decisions.

KidneyIntelX: The proven prognostic solution to improve kidney health. It’s bioprognosis.2023-02-26T17:03:35+00:00

Diverse data inputs, all proven to be prognostic for kidney disease progression, specifically, based on multiple, third-party, clinical studies

  • Real-time, patient blood draw
  • 3 proprietary, blood-based biomarker concentrations (TNFR-1, TNFR-2, KIM-1), each robustly validated by multiple third-party studies
  • 2 additional biomarker ratios
  • Inclusion of clinical factors, derived from patients’ Electronic Health Records, that add to prognostic accuracy of KidneyIntelX
KidneyIntelX: Designed to integrate with all types of clinical workflows.2023-02-26T16:52:14+00:00

Innovative prognostics are only as effective as their level of integration in clinical workflows. That’s why we’ve architected KidneyIntelX to integrate:

  • With any kind of clinical workflow, including big health systems and smaller, independent practices
  • With electronic health records, sharing data to calculate the KidneyIntelX risk score and to deliver the results to drive positive patient outcomes
KidneyIntelX: Technology can help but can never replace an experienced and human touch.2023-02-26T16:37:34+00:00

We recognize and champion the doctor’s ability to work with his/her patients in the earliest stages to develop the best and most customized, care plan. Further, we provide robust educational resources and timely, practical support.

Our out-of-the-gate focus: Diabetic Kidney Disease.

Diabetes is the leading cause of chronic kidney disease, representing nearly 40% of its cases. That’s why our first KidneyIntelX indication is focused on diabetic kidney disease.
(Source: › content › 12/12/2032)

And our test platform eliminates the grey area common in diabetic kidney disease.

Currently, doctors are unable to determine which of the 1 in 5 patients with type 2 diabetes and chronic kidney disease are at the highest risk for rapid progressive decline in kidney function – vs those who are at lower risk. KidneyIntelX is the only test that identifies which patients are at higher-to-lower risk to help guide an actionable, targeted plan for what’s next.

KidneyIntelX. Designed to be scalable. Additional discoveries and developments in novel biomarkers, expanded clinical indications and integrated digital technologies.

Our KidneyIntelX platform is designed to scale across kidney disease conditions beyond diabetic kidney disease. We are evaluating a range of new indications in chronic kidney disease, cardio-renal disease, chronic kidney disease in diverse populations and COVID-related kidney disease. We’re also continuing our next generation work on our current diabetic kidney disease indication while we explore ways to expand access to patients around the world.

Critical to our platform is also the ability to stay at the forefront of cloud based digital health technology, data integration and data analytics, which we’re accomplishing through our Digital Health Team, various strategic partnerships and our participation in how category regulations should evolve. All of these will enable the most effective data-driven decision making and care delivery across the healthcare system and for each patient.

New indications are on the horizon with our KidneyIntelX platform:

  • Risk assessment and care insights for Chronic Kidney Disease
  • Diabetic Kidney Disease and Chronic Kidney Disease monitoring tests, beyond the initial risk assessment

We’re fortunate to have great collaborators.
And more partnerships are in the works.

“Our partnership with Renalytix aims to improve kidney risk stratification in type-2 diabetes… their (solution) uses artificial intelligence to evaluate the combination of important kidney function biomarkers and electronic health record information.”

Joseph Vassalotti, MD
Chief Medical Officer, National Kidney Foundation

“Renalytix is linking molecular mechanisms and patient data with educational tools to drive a rigorous, clinically-validated and new model of care in kidney disease.”

Prof. Matthias Kretzler

Warner-Lambert/Parke-Davis Professor of Medicine, Nephrology/Internal Medicine, and Computational Medicine and Bioinformatics (University of Michigan Medical School)*

*Title provided for identification purposes only. The views and opinions expressed are those of the individual only and do not necessarily reflect the positions of University of Michigan.

“Together, we are committed to revolutionizing kidney care… by identifying patients with significant unmet needs and providing them with more personalized interventions.”

Tarek Rabah

Vice President of U.S. Renal-Cardio, AstraZeneca

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